کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8684386 | 1579994 | 2018 | 24 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Initial clinical presentation of young children with N-methyl-d-aspartate receptor encephalitis
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کلمات کلیدی
FDG-PETN-methyl-d-aspartateNMDAIQRHSVENTMRSABSantibodies - آنتی بادی هاAutoimmune encephalitis - آنسفالیت اتوایمیونFLAIR - اشتباهElectroencephalogram - الکتروانسفالوگرافیMRI - امآرآی یا تصویرسازی تشدید مغناطیسیfluid attenuated inversion recovery - بهبود مورفین مایع کاهش می یابدFocal seizures - تشنج متمرکزMagnetic resonance imaging - تصویربرداری رزونانس مغناطیسیCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیinterquartile range - محدوده بین محدبModified Rankin scale - مقیاس رنکین اصلاح شدهEEG - نوار مغزیherpes simplex virus - ویروس هرپس سیمپلکسChild - کودکear, nose and throat - گوش و حلق و بینیN-methyl-d-aspartate receptor - گیرنده N-methyl-d-aspartate
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
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چکیده انگلیسی
Autoimmune encephalitis with anti-N-methyl-d-aspartate receptor autoantibodies (NMDA-R-Abs) is a recently described disease affecting adult and pediatric patients. Symptoms of the disease are now perfectly described in the adult population but the clinical presentation is less known in young children. The aim of the present study was to describe the clinical presentation and the specificities of symptoms presented by young children with NMDA-R-Abs encephalitis to improve diagnosis of this disease, and to compare these to a series of previously published female adult patients. Fifty cases of children younger than twelve years of age diagnosed with NMDA-R-Abs encephalitis between January 1, 2007 and December 31, 2016 (27 females and 23 males) were retrospectively studied. The first neurological symptoms observed in young children with NMDA-R-Abs encephalitis were characterized by seizure (72%), especially focal seizure (42%), within a median of 15 days before other encephalitis symptoms; other patients mostly had behavioral disorders (26%). The seizures were frequently difficult to diagnose because of the transient unilateral dystonic or tonic posturing presentation or sudden unilateral pain in the absence of clonic movements. A post-ictal motor deficit was also frequently observed. This clinical presentation is different from that observed in adult females with NMDA-R-Abs encephalitis who initially present mainly psychiatric disorders (67%) or cognitive impairment (19%), and less frequently seizures (14%). The diagnosis of NMDA-R-Abs encephalitis should be systematically considered in young children of both sexes who present neurological symptoms suggesting recent seizures (focal or generalized) without obvious other etiology.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Journal of Paediatric Neurology - Volume 22, Issue 3, May 2018, Pages 404-411
Journal: European Journal of Paediatric Neurology - Volume 22, Issue 3, May 2018, Pages 404-411
نویسندگان
Marion Favier, Bastien Joubert, Géraldine Picard, Véronique Rogemond, Laure Thomas, Sylvain Rheims, Marion Bailhache, Frédéric Villega, Jean-Michel Pédespan, Giulia Berzero, Dimitri Psimaras, Jean-Christophe Antoine, Virginie Desestret,