کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8685343 1580269 2018 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
How immunotherapies are targeting the glioblastoma immune environment
ترجمه فارسی عنوان
چگونه ایمنوتراپی محیط زیست ایمنی گلوبلاستوما را هدف قرار می دهد
کلمات کلیدی
گلیوبلاستوما، ایمونوتراپی، انتقال متقابل، ایمن سازی، منفعل، واکسن های سرطانی،
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی عصب شناسی
چکیده انگلیسی
The diagnosis of glioblastoma remains one of the most dismal in medical practice, with current standard care only providing a median survival of 14.6 months. The need for new therapies is desperately clear. Components of the tumour microenvironment are demonstrating growing importance in the field, given they allow the tumour to utilise pathways involved in autoimmune prevention, something that enables the tumour's establishment and growth. As with many different cancers, the search for a new standard has progressed to the design of immunotherapies, which aim to counteract the immune changes within this microenvironment. Serotherapy, adoptive lymphocyte transfer, peptide and dendritic cell vaccines and a range of other methods are currently under investigation, while intracranial infection has also been researched for its capacity to reverse glioblastoma mediated immunosuppression. Some of these new therapies have shown promise, but it is a long road ahead before their incorporation into glioblastoma standard therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 47, January 2018, Pages 20-27
نویسندگان
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