کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8685422 | 1580269 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Patient and treatment factors associated with survival among pediatric glioblastoma patients: A Surveillance, Epidemiology, and End Results study
ترجمه فارسی عنوان
بیمار و عوامل درمان مرتبط با بقا در بیماران مبتلا به گلوبلاستوم اطفال: مطالعه ای از نوع نظارت، اپیدمیولوژی و نتایج پایانی
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
چکیده انگلیسی
Glioblastoma (GBM) is a rare malignancy in children. The United States Surveillance, Epidemiology, and End Results (SEER) database allows large-scale analyses of clinical characteristics and prognostic features. We used it to study patients aged <20â¯years with histologically confirmed GBM (2000-2010) and examined the relationship between patient demographics, tumor characteristics, patterns of treatment, and outcomes. The primary outcome was disease-specific survival. 302 subjects were identified, with median age 11â¯years. Median follow-up was 32â¯months (95% CI 27-39). 34.4% had gross total resection (GTR). 61% underwent radiation after surgery (17% of subjects <3â¯years, 67% of those aged 4-19â¯years). Median survival and 2-year survival rates were 20â¯months and 46.9%, respectively. In multivariate analyses, age, tumor location, extent of resection, and year of diagnosis were significantly associated with the primary outcome. Compared to those aged 0-4â¯years, subjects aged 5-9â¯years and 10-14â¯years had higher risk of mortality. Infratentorial tumor location (HR 2.0, 95% CI 1.2-3.3, pâ¯=â¯0.007) and subtotal resection (HR 2.04, 95% CI 1.4-3.0, pâ¯<â¯0.001) were associated with increased mortality. Later year of diagnosis was significantly associated with decreased risk of death (HR 0.93, 95% CI 0.9-0.99, pâ¯=â¯0.031). There was no association between sex, race, region, or tumor size and the primary outcome. Repeat analyses examining all-cause mortality identified the same risk factors as for CNS cancer-specific mortality. Younger age, supratentorial location, GTR, and later year of diagnosis were associated with improved survival.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Clinical Neuroscience - Volume 47, January 2018, Pages 285-293
Journal: Journal of Clinical Neuroscience - Volume 47, January 2018, Pages 285-293
نویسندگان
Sandi Lam, Yimo Lin, Pascal Zinn, Jack Su, I-Wen Pan,