کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8685616 | 1580352 | 2018 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Calcitonin gene-related peptide decreases IL-1beta, IL-6 as well as Ym1, Arg1, CD163 expression in a brain tissue context-dependent manner while ameliorating experimental autoimmune encephalomyelitis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
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چکیده انگلیسی
Amelioration of signs of experimental autoimmune encephalomyelitis (EAE, a multiple sclerosis model) that is induced by intrathecal delivery of CGRP neuropeptide, is accompanied by a context-dependent decrease in expression of markers associated to opposite inflammatory activity profiles in EAE, pro-inflammatory markers (IL-1 beta and IL-6) as well as anti-inflammatory markers (Ym1/Chil3, Arg1, CD163). It is hypothesized that, by this novel mechanism, CGRP promotes down-regulation of immune cell activation that facilitates the establishment of a beneficial environment in EAE provided also by other factors.192
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 323, 15 October 2018, Pages 94-104
Journal: Journal of Neuroimmunology - Volume 323, 15 October 2018, Pages 94-104
نویسندگان
Ilaria Rossetti, Laura Zambusi, Annamaria Finardi, Antonella Bodini, Luciano Provini, Roberto Furlan, Stefano Morara,