کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8686627 | 1580830 | 2018 | 35 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuroplasticity in the cerebello-thalamo-basal ganglia pathway: AÂ longitudinal in vivo MRI study in male songbirds
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کلمات کلیدی
PMPROIDTIDLMHVCMRI - امآرآی یا تصویرسازی تشدید مغناطیسیAFP - تست AFP یا آلفا فیتو پروتئینSAP - شیرهbasal ganglia - عقدههای قاعدهایLMAN - لمنsongbird - مرغان آوازخوان، پرنده آواز خوانanterior forebrain pathway - مسیر پیشروی پیشانیregion-of-interest - منطقه مورد نظرrobust nucleus of the arcopallium - هسته قوی آرکوپالیمlateral magnocellular nucleus of the anterior nidopallium - هسته مغناطیسی جانبی جانبی نیدوپالیم قدامی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuroplasticity in the cerebello-thalamo-basal ganglia pathway: AÂ longitudinal in vivo MRI study in male songbirds Neuroplasticity in the cerebello-thalamo-basal ganglia pathway: AÂ longitudinal in vivo MRI study in male songbirds](/preview/png/8686627.png)
چکیده انگلیسی
Similar to human speech, bird song is controlled by several pathways including a cortico-basal ganglia-thalamo-cortical (C-BG-T-C) loop. Neurotoxic disengagement of the basal ganglia component, i.e. Area X, induces long-term changes in song performance, while most of the lesioned area regenerates within the first months. Importantly however, the timing and spatial extent of structural neuroplastic events potentially affecting other constituents of the C-BG-T-C loop is not clear. We designed a longitudinal MRI study where changes in brain structure were evaluated relative to the time after neurotoxic lesioning or to vocal performance. By acquiring both Diffusion Tensor Imaging and 3-dimensional anatomical scans, we were able to track alterations in respectively intrinsic tissue properties and local volume. Voxel-based statistical analyses revealed structural remodeling remote to the lesion, i.e. in the thalamus and, surprisingly, the cerebellum, both peaking within the first two months after lesioning Area X. Voxel-wise correlations between song performance and MRI parameters uncovered intriguing brain-behavior relationships in several brain areas pertaining to the C-BG-T-C loop supervising vocal motor control. Our results clearly point to structural neuroplasticity in the cerebellum induced by basal ganglia (striatal) damage and might point to the existence of a human-like cerebello-thalamic-basal ganglia pathway capable of modifying vocal motor output.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 181, 1 November 2018, Pages 190-202
Journal: NeuroImage - Volume 181, 1 November 2018, Pages 190-202
نویسندگان
Julie Hamaide, Kristina Lukacova, Johan Van Audekerke, Marleen Verhoye, Lubica Kubikova, Annemie Van der Linden,