کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8687425 | 1580846 | 2018 | 38 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Techniques for blood volume fMRI with VASO: From low-resolution mapping towards sub-millimeter layer-dependent applications
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کلمات کلیدی
ROICNRCBVSNRBOLDFOVSAREPIecho planar imaging - تصویر برداری اکو فلاریfMRI - تصویرسازی تشدید مغناطیسی کارکردیfunctional magnetic resonance imaging - تصویرسازی تشدید مغناطیسی کارکردیCerebral blood volume - حجم خون مغزیblood oxygenation level dependent - سطح اکسیژن خون وابسته استgrey matter - ماده خاکستریCSF - مایع مغزی نخاعیCerebrospinal fluid - مایع مغزی نخاعیregion of interest - منطقه مورد نظرField of view - میدان دیدspecific absorption rate - نرخ جذب خاصSignal-to-noise ratio - نسبت سیگنال به نویزContrast-to-noise ratio - نسبت کنتراست به نویزControlled Aliasing In Parallel Imaging Results In Higher Acceleration - کنترل نامناسبی در نتایج همزمان تصویربرداری در شتاب بیشترGradient echo - گرادیان اکو
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب شناختی
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چکیده انگلیسی
Quantitative cerebral blood volume (CBV) fMRI has the potential to overcome several specific limitations of BOLD fMRI. It provides direct physiological interpretability and promises superior localization specificity in applications of sub-millimeter resolution fMRI applications at ultra-high magnetic fields (7Â T and higher). Non-invasive CBV fMRI using VASO (vascular space occupancy), however, is inherently limited with respect to its data acquisition efficiency, restricting its imaging coverage and achievable spatial and temporal resolution. This limitation may be reduced with recent advanced acceleration and reconstruction strategies that allow two-dimensional acceleration, such as in simultaneous multi-slice (SMS) 2D-EPI or 3D-EPI in combination with CAIPIRINHA field-of-view shifting. In this study, we sought to determine the functional sensitivity and specificity of these readout strategies with VASO over a broad range of spatial resolutions; spanning from low spatial resolution (3Â mm) whole-cortex to sub-millimeter (0.75Â mm) slab-of-cortex (for cortical layer-dependent applications). In the thermal-noise-dominated regime of sub-millimeter resolutions, 3D-EPI-VASO provides higher temporal stability and sensitivity to detect changes in CBV compared to 2D-EPI-VASO. In this regime, 3D-EPI-VASO unveils task activation located in the cortical laminae with little contamination from surface veins, in contrast to the cortical surface weighting of GE-BOLD fMRI. In the physiological-noise-dominated regime of lower resolutions, however, 2D-SMS-VASO shows superior performance compared to 3D-EPI-VASO. Due to its superior sensitivity at a layer-dependent level, 3D-EPI VASO promises to play an important role in future neuroscientific applications of layer-dependent fMRI.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NeuroImage - Volume 164, 1 January 2018, Pages 131-143
Journal: NeuroImage - Volume 164, 1 January 2018, Pages 131-143
نویسندگان
Laurentius Huber, Dimo Ivanov, Daniel A. Handwerker, Sean Marrett, Maria Guidi, Kâmil UludaÄ, Peter A. Bandettini, Benedikt A. Poser,