کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8690007 | 1581099 | 2018 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The cortical excitability profile of patients with the G209A SNCA mutation versus patients with sporadic Parkinson's disease: A transcranial magnetic stimulation study
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Mutations in the α-synuclein gene are a rare cause of Parkinson's disease. We investigated, by single-pulse TMS, the cortical excitability profile of nine α-synuclein patients in comparison with 24 idiopathic PD patients, subdivided into “akinetic” (n = 17) and “tremor-dominant” (n = 7) subgroups. The comparative assessment of rest motor threshold, active MEP and Silent Period Input/Output curves indicated that the cortical excitability of α-Synuclein patients is similar to patients with the “akinetic” form of PD. Both groups of patients exhibited differences in excitatory and inhibitory brain circuits from “tremor-dominant” patients indicating that varying clinical phenotypes are associated with differential profiles of corticospinal excitability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurophysiologie Clinique - Volume 48, Issue 4, September 2018, Pages 203-206
Journal: Neurophysiologie Clinique - Volume 48, Issue 4, September 2018, Pages 203-206
نویسندگان
Vasilios K. Kimiskidis, Sotirios Papayiannopoulos, Kyriaki Sotirakoglou, Haralambos Karakasis, Zoe Katsarou, Dimitrios A. Kazis, Vasileios Papaliagkas, Stylianos Gatzonis, Alexandros Papadimitriou, Georgios Hadjigeorgiou, Sevasti Bostanjopoulou,