کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8697893 1584095 2018 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The expression of endogenous hydrogen sulfide signal during distraction osteogenesis in a rabbit model
ترجمه فارسی عنوان
بیان سیگنال هیدروژن سولفید درونی در هنگام استئوژنز منحرف کردن در یک مدل خرگوش
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی دندانپزشکی، جراحی دهان و پزشکی
چکیده انگلیسی
The hydrogen sulfide (H2S) signal system plays an important role in bone metabolism. However, the role of endogenous H2S during distraction osteogenesis (DO) remains unclear. Sixty-two male New Zealand White rabbits were subjected to right mandibular DO. Before distraction, the animals were divided randomly into two groups: group A, 0.5 mm twice/day for 10 days; group B, 1.25 mm twice/day for 4 days. Plasma and distraction gap tissue were harvested to determine the H2S signal. The osteogenesis effect was also evaluated. The newly regenerated bone in group A presented a higher level of mineralization and biomechanical strength than that in group B. The bone mineralization density in group A was 1.95-fold that in group B (P = 0.028), while the biomechanical strength in group A was 1.26-fold that in group B (P = 0.042) at the end of the experiment. The H2S signal was detected during the whole process of DO. The relative plasma H2S concentrations in group A were noticeably higher than those in group B at the middle of distraction (P < 0.001), at the end of the distraction (P = 0.034), and 2 weeks after the end of distraction (P = 0.002). The results suggest that the endogenous H2S signal system plays a major role during DO.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Oral and Maxillofacial Surgery - Volume 47, Issue 2, February 2018, Pages 262-267
نویسندگان
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