کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8698955 | 1585433 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Determination of VEGF, collagen type 1 and versican in the discus articularis of the temporomandibular joint in relation to dental status
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
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چکیده انگلیسی
The aim of this study was the investigation and comparison of the presence of vascular endothelial growth factor (VEGF), collagen type 1 and the proteoglycan versican in the discus articularis in relation to dental status (full dentition [1], partial dentition [2] and edentulous [3]). The right disci articulares were removed from 17 donated bodies (6 with full dentition, 5 with partial dentition and 6 edentulous). The specimens were immunohistochemically stained for VEGF, collagen type 1 and versican. Semiquantitative analysis of the disci was conducted within the groups based on the intensity of immunoreactivity of VEGF, collagen type 1 and versican. In addition, a pairwise comparison was carried out between the three experimental groups. The results revealed significantly higher immunoreactivity for VEGF and versican in groups 2 and 3 than in group 1. Conversely, determination of immunoreactivity was significantly higher in group 1 for collagen type 1 than in the other two groups. These results indicate an elevated presence of the proteoglycan versican and the neoangiogenesis factor VEGF when the occlusal supporting zone has been lost. By contrast, detection of collagen type 1 is reduced. The loss of collagen type 1 and rise in versican and VEGF suggest increasing degeneration when the supporting zone is lost due to the loss of teeth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cranio-Maxillofacial Surgery - Volume 46, Issue 1, January 2018, Pages 67-74
Journal: Journal of Cranio-Maxillofacial Surgery - Volume 46, Issue 1, January 2018, Pages 67-74
نویسندگان
Malte Michaelis, Ralph Lucius, Jörg Wiltfang, Falk Birkenfeld,