کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8723559 1589634 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Des essais randomisés contrôlés aux études observationnelles. Apports, limites et leçons. Réflexions à propos de l'étude ODYSSEE
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Des essais randomisés contrôlés aux études observationnelles. Apports, limites et leçons. Réflexions à propos de l'étude ODYSSEE
چکیده انگلیسی
Randomized controlled trials (RCT) are considered as the gold standard in the hierarchy of research designs for evaluating the efficacy and safety of a treatment intervention. They have long been regarded as the sole basis of the evidence-based medicine (EBM). Nevertheless, their conclusions can have limited applicability to patients in clinical settings. Observational studies using large health care databases can complement findings from RCT by assessing treatment effectiveness in patients encountered in day-to-day clinical practice. Results from these designs can expand upon outcomes of RCT because of the use of larger and more diverse patient populations with common comorbidities and longer follow-up periods. Furthermore, well-designed observational studies can identify clinically important differences among therapeutic options and provide data on long-term drug effectiveness and safety.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Médecine des Maladies Métaboliques - Volume 10, Issue 8, December 2016, Pages 732-740
نویسندگان
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