Resveratrol promotes the arcuate nucleus architecture remodeling to produce more anorexigenic neurons in high-fat-diet-fed mice

- The effects of resveratrol (RSV) on hypothalamic architecture were investigated in a diet-induced obesity model of mice.
- Both high-fat (HF) and HF + RSV diets increased the number of new cells in the arcuate nucleus of the hypothalamus.
- Although an HF diet induced the production of neuropeptide Y neurons from newborn cells, adding RSV to the HF diet changed the fate of new cells to proopiomelanocortin neurons.