کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8727077 | 1590033 | 2018 | 31 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Historical Perspectives and Advances in Mesenchymal Stem Cell Research for the Treatment of Liver Diseases
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کلمات کلیدی
HpSCBALHSCCCl4PSCHLCHGFMSCIPSCsECM3-dimensional - 3 بعدیHepatocytes - hepatocyteshESC - hescinterleukin - اینترلوکینStem cell therapy - درمان با سلول های بنیادیHuman embryonic stem cell - سلول بنیادی جنینی انسانHuman pluripotent stem cell - سلول بنیادی پلورپوفنت انسانیHepatic stellate cell - سلول ستاره ای کبدیMesenchymal stem cell - سلول های بنیادی مزانشیمیInduced pluripotent stem cells - سلول های بنیادی پرتوان القاییPluripotent stem cells - سلول های بنیادی پلوروپتوژنPluripotent stem cell - سلول های بنیادی پلوروپتوژنhepatocyte-like cell - سلول هپاتوسیت مانندHepatocyte growth factor - عامل رشد هپاتوسیتExtracellular matrix - ماتریکس خارج سلولیRegenerative medicine - پزشکی ترمیمیCarbon tetrachloride - کربن تتراکلرید
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Liver transplantation is the only effective therapy for patients with decompensated cirrhosis and fulminant liver failure. However, due to a shortage of donor livers and complications associated with immune suppression, there is an urgent need for new therapeutic strategies for patients with end-stage liver diseases. Given their unique function in self-renewal and differentiation potential, stem cells might be used to regenerate damaged liver tissue. Recent studies have shown that stem cellâbased therapies can improve liver function in a mouse model of hepatic failure. Moreover, acellular liver scaffolds seeded with hepatocytes produced functional bioengineered livers for organ transplantation in preclinical studies. The therapeutic potential of stem cells or their differentiated progenies will depend on their capacity to differentiate into mature and functional cell types after transplantation. It will also be important to devise methods to overcome their genomic instability, immune reactivity, and tumorigenic potential. We review directions and advances in the use of mesenchymal stem cells and their derived hepatocytes for liver regeneration. We also discuss the potential applications of hepatocytes derived from human pluripotent stem cells and challenges to using these cells in treating end-stage liver disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gastroenterology - Volume 154, Issue 1, January 2018, Pages 46-56
Journal: Gastroenterology - Volume 154, Issue 1, January 2018, Pages 46-56
نویسندگان
Chien-Wei Lee, Yu-Fan Chen, Hao-Hsiang Wu, Oscar K. Lee,