کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8728796 | 1590301 | 2018 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
La préservation de la fertilité ultérieure dans les cancers pédiatriques
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای گوارشی
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چکیده انگلیسی
The cure rate for childhood and adolescent patients with cancer has currently reached almost 80Â % and protecting future fertility and thereby promoting quality of life have become a major challenge in the care of these patients (Bioethics Law 2004). Age, sex and associated treatments influence the risk of future subfertility. Certain chemotherapies (particularly alkylating agents) and radiotherapy fields that include the gonads or hypothalamopituitary axis may negatively impact the future fertility of patients. Evaluation of the gonadotoxic potential of therapeutic measures and the utilization of appropriate methods to preserve fertility require the combined efforts of a multidisciplinary team that includes pediatric oncologists, radiotherapists, surgeons, reproductive physicians and biologists, and psychologists. Techniques for fertility preservation vary depending on the age of the child and range from surgical transposition of the gonads for pelvic radiotherapy to cryopreservation of the ovary or testicle in case of sterilizing chemotherapy. While scientists still do not yet fully understand the maturation of immature germ cells, these children will be seeking the assistance of Medically Assisted Procreation (MAP) in 20-30Â years. In the meanwhile, it is to be hoped that many more advances will be achieved in the utilization of harvested germinal tissue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal de Chirurgie Viscérale - Volume 155, Supplement 1, June 2018, Pages S40-S46
Journal: Journal de Chirurgie Viscérale - Volume 155, Supplement 1, June 2018, Pages S40-S46
نویسندگان
G. de Lambert, C. Poirot, F. Guérin, L. Brugières, H. Martelli,