کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8734789 1590996 2018 21 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Novel Sickle Cell Disease Therapies: Targeting Pathways Downstream of Sickling
ترجمه فارسی عنوان
درمان بیماری های سلولی رمان: هدف گیری مسیرهای پایین سیکلینگ
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی هماتولوژی
چکیده انگلیسی
Sickle cell disease is an inherited hemoglobinopathy characterized by hemolytic anemia, frequent painful episodes, poor quality of life, end organ damage and a shortened lifespan. Although the seminal event is the polymerization of the abnormal hemoglobin, the downstream pathophysiology of vaso-occlusion results from heterotypic interactions between the altered, adhesive sickle cell RBCs, neutrophils, endothelium, and platelets. Ischemia reperfusion injury, hemolysis and oxidant damage all contribute to heightened inflammation and activation of the hemostatic system. These downstream targets are the focus of emerging treatments with considerable potential to ameliorate disease manifestations. This review summarizes the progress on development of these agents.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Hematology - Volume 55, Issue 2, April 2018, Pages 68-75
نویسندگان
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