کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8737334 | 1591331 | 2018 | 20 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Antibody test for Legionella pneumophila detection
ترجمه فارسی عنوان
آزمون آنتیبادی برای تشخیص لژیونلا پنوموفیلا
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کلمات کلیدی
لژیونلا، پادتن، تشخیص واکنش پذیری متقابل،
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
میکروبیولوژی و بیوتکنولوژی کاربردی
چکیده انگلیسی
Legionella pneumophila is responsible for Legionnaires' disease (LD). Its detection in both environmental and clinical samples is mainly performed by culture plate method which requires up to 10Â days to obtain results. Nowadays, there are commercial antibodies against this bacterium, but they have not been tested against all subgroups of L. pneumophila sg 1 or serogroups 1-16 or their cross-reactions with other non-Legionella bacteria. Indeed, many of these antibodies became available when only 8 serogroups of L. pneumophila had been described. We tested 7 antibodies and found that 2 (Mab 8/5 and OBT) specifically detected all the subgroups of L. pneumophila sg 1, one without cross-reactions (Mab8/5). Moreover, the LP3IIG2 antibody detected almost all serogroups tested with lower rates of cross-reactivity, resulting in a specific sensitive antibody for the detection of L. pneumophila. LP3IIG2 presented higher rate of cross-reactivity against respiratory non-Legionella isolates, thereby contraindicating its clinical applicability.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 90, Issue 2, February 2018, Pages 85-89
Journal: Diagnostic Microbiology and Infectious Disease - Volume 90, Issue 2, February 2018, Pages 85-89
نویسندگان
Noemà Párraga-Niño, Sara Quero, Naroa Uria, Oscar Castillo-Fernandez, Josune Jimenez-Ezenarro, Francesc-Xavier Muñoz, Miquel Sabrià , Marian Garcia-Nuñez,