کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8737679 | 1591370 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
KIR-HLA distribution in a Vietnamese population from Hanoi
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ایمونولوژی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The KIR (killer cell immunoglobulin-like receptors) gene family codifies a group of receptors that recognize human leukocyte antigens (HLA) and modulate natural killer (NK) cells response. Genetic diversity of KIR genes and HLA ligands has not yet been deeply investigated in South East Asia. Here, we characterized KIR gene presence and absence polymorphism of 14 KIR genes and two pseudogenes, as well as the frequencies of the ligands HLA-Bw4, HLA-C1 and HLA-C2 in a Vietnamese population from Hanoi (nâ¯=â¯140). Genotyping was performed by polymerase chain reaction with specific sequence primers (PCR-SSP). We compared KIR frequencies and performed principal component analysis with 43 worldwide populations of different ancestries. KIR carrier frequencies in Vietnamese were similar to those reported for Thai and Chinese Han, but differed significantly from other geographically close populations such as Japanese and South Korean. This similarity was also observed in KIR gene-content genotypes and is in accordance with the origin from Southern China and Thailand proposed for the Vietnamese population. The frequencies of HLA ligands observed in Vietnamese did not differ from those reported for other East-Asian populations (pâ¯>â¯.05). Studies regarding KIR-HLA in populations are of prime importance to understand their evolution, function and role in diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Immunology - Volume 79, Issue 2, February 2018, Pages 93-100
Journal: Human Immunology - Volume 79, Issue 2, February 2018, Pages 93-100
نویسندگان
Leonardo Maldaner Amorim, Hoang van Tong, Nghiem Xuan Hoan, Luciana de Brito Vargas, Enilze Maria de Souza Fonseca Ribeiro, Maria Luiza Petzl-Erler, Angelica B.W. Boldt, Nguyen Linh Toan, Le Huu Song, Thirumalaisamy P. Velavan, Danillo G. Augusto,