کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8743144 | 1592522 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
FcÉRI et MRGPRX2Â régulent différemment la dynamique de dégranulation des mastocytes
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
ایمونولوژی، آلرژی و روماتولوژی
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چکیده انگلیسی
Mast cells are granular immune cells strategically located among connective tissues and mucosa, where they participate to the regulation of diverse inflammatory processes. The principal characteristic of mast cells is their capacity to rapidly exteriorize intracellular granular content enriched in bioactive molecules in response to different activation signals. A better understanding of how these cells regulate their secretion dynamics under different stimulatory conditions is crucial to apprehend mast cell-dependent inflammatory reactions. We particularly focused on mast cell activation via two major receptors involved in diverse pathophysiological processes: FcÉRI (the high affinity receptor for IgE) and MRGPRX2 (the mast cell receptor for cationic molecules). To circumvent existing technical constraints, we developed a new approach that permits to monitor, in real-time and at the single cell level, mast cell degranulation dynamics using in vitro confocal microscopy and in vivo two-photon microscopy. We found that mast cell translate FcÉRI- or MRGPRX2-mediated signals into distinct degranulation strategies leading to the release of granular content with specific physical characteristics and the development of mast cell-dependent reactions of different intensities. Here we propose a synthesis of new concept on how mast cells regulate their degranulation strategy in response to activation via different receptors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Revue Française d'Allergologie - Volume 58, Issue 2, March 2018, Pages 101-105
Journal: Revue Française d'Allergologie - Volume 58, Issue 2, March 2018, Pages 101-105
نویسندگان
N. Gaudenzio,