کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8753096 1594870 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The impact of uterine immaturity on obstetrical syndromes during adolescence
ترجمه فارسی عنوان
تأثیر ناتوانی رحم در سندرم های زنان باردار در طی نوجوانی
کلمات کلیدی
حاملگی نوجوانان، چاقی، قرار دادن، سندرم تخمدان پلی کیستیک، پره اکلامپسی، زایمان زودرس، مقاومت پروژسترون، سلول های بنیادی، بلوغ رحم، سلول های قاتل طبیعی رحم،
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
Pregnant nulliparous adolescents are at increased risk, inversely proportional to their age, of major obstetric syndromes, including preeclampsia, fetal growth restriction, and preterm birth. Emerging evidence indicates that biological immaturity of the uterus accounts for the increased incidence of obstetrical disorders in very young mothers, possibly compounded by sociodemographic factors associated with teenage pregnancy. The endometrium in most newborns is intrinsically resistant to progesterone signaling, and the rate of transition to a fully responsive tissue likely determines pregnancy outcome during adolescence. In addition to ontogenetic progesterone resistance, other factors appear important for the transition of the immature uterus to a functional organ, including estrogen-dependent growth and tissue-specific conditioning of uterine natural killer cells, which plays a critical role in vascular adaptation during pregnancy. The perivascular space around the spiral arteries is rich in endometrial mesenchymal stem-like cells, and dynamic changes in this niche are essential to accommodate endovascular trophoblast invasion and deep placentation. Here we evaluate the intrinsic (uterine-specific) mechanisms that predispose adolescent mothers to the great obstetrical syndromes and discuss the convergence of extrinsic risk factors that may be amenable to intervention.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Obstetrics and Gynecology - Volume 217, Issue 5, November 2017, Pages 546-555
نویسندگان
, , , , , , , , ,