کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8757449 | 1596404 | 2018 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Design and rationale of the “Sedation strategy and cognitive outcome after critical illness in early childhood” study
ترجمه فارسی عنوان
طراحی و منطق استراتژی رسمی و پیامدهای شناختی پس از بیماری بحرانی در اوایل دوران کودکی مطالعه
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کلمات کلیدی
نتایج بهداشتی، نارسایی تنفسی، اطفال، سندرم مراقبت پس از شدت،
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
چکیده انگلیسی
There is increasing concern that sedatives commonly used during critical illness may be neurotoxic during the period of early brain development. The Sedation strategy and cognitive outcome after critical illness in early childhood (RESTORE-cognition) study is a prospective cohort study designed to examine the relationships between sedative exposure during pediatric critical illness and long-term neurocognitive outcomes. We assess multiple domains of neurocognitive function 2.5-5â¯years post-hospital discharge, at a single time point and depending on participant and clinician availability, in up to 500 subjects who had normal baseline cognitive function, were aged 2â¯weeks to 8â¯years at pediatric intensive care unit admission, and were enrolled in a cluster randomized controlled trial of a sedation protocol (the RESTORE trial; U01 HL086622 and HL086649). In addition, to provide comparable data on an unexposed group with similar baseline biological characteristics and environment, we are studying matched, healthy siblings of RESTORE patients. Our goal is to increase understanding of the relationships between sedative exposure, critical illness, and long-term neurocognitive outcomes in infants and young children by studying these subjects 2.5 to 5â¯years after their index hospitalization. This paper highlights the design challenges in conducting comprehensive neurocognitive assessment procedures across a broad age span at multiple testing centers across the United States. Our approach, which includes building interprofessional teams and novel cohort retention strategies, may be of help in future longitudinal trials.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Contemporary Clinical Trials - Volume 72, September 2018, Pages 8-15
Journal: Contemporary Clinical Trials - Volume 72, September 2018, Pages 8-15
نویسندگان
Martha A.Q. Curley, R. Scott Watson, Amy M. Cassidy, Cheryl Burns, Rachel L. Delinger, Derek C. Angus, Lisa A. Asaro, David Wypij, Sue R. Beers, for the RESTORE-cognition Study Investigators for the RESTORE-cognition Study Investigators,