کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8764088 | 1597467 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sjögren's syndrome
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی و دندانپزشکی (عمومی)
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چکیده انگلیسی
Sjögren's syndrome (SS) is a systemic autoimmune disorder characterized by focal inflammation of the exocrine glands, leading to dry eyes and dry mouth. Two forms of the syndrome have been defined: primary (pSS), in which dysfunction of the exocrine glands occurs in the absence of other autoimmune diseases, and secondary, in which patients suffer additional autoimmune processes, especially connective tissue disorders such as rheumatoid arthritis, systemic lupus erythematosus and scleroderma. About 70% of patients with pSS have anti-Ro and/or anti-La autoantibodies. Hypergammaglobulinaemia is also common, and a proportion of patients have systemic involvement. Better use of symptomatic therapies can make a big difference to patients, and there is also current interest in whether biological therapies could be effective in treating pSS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medicine - Volume 46, Issue 2, February 2018, Pages 126-130
Journal: Medicine - Volume 46, Issue 2, February 2018, Pages 126-130
نویسندگان
Alexandre Dumusc, Vijay Rao, Simon J. Bowman,