Disorders of bone metabolism

Bone remodelling is critical to bone health. Alterations in the normal processes and regulation of remodelling may impact on bone mass and bone strength. Changes may be generalized or focal and underlie many of the common disorders of bone metabolism. This article focuses on the changes in bone remodelling which underlie both the development and treatment of osteoporosis. Osteomalacia, as an example of a mineralization disorder and Paget's disease as an example of a focal disorder of bone remodelling, are also briefly reviewed.