کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8770048 | 1598219 | 2017 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis
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کلمات کلیدی
acute kidney injury (AKI) - آسیب حاد کلیه (AKI)myeloproliferative disorder - اختلال میلولپرولیفراتیوKidney biopsy - بیوپسی کلیهExtramedullary hematopoiesis - خونریزی Extramedullarynephrotic syndrome - سندرم نفروتیکJAK inhibitor - مهار کننده چقدر استMyelofibrosis - میلوفیبروزmembranous nephropathy - نفروپاتی غشاییProteinuria - پروتئینوریCase report - گزارش موردیGlomerulonephritis - گلومرولونفریت
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis Membranous Nephropathy and Intrarenal Extramedullary Hematopoiesis in a Patient With Myelofibrosis](/preview/png/8770048.png)
چکیده انگلیسی
Kidney disease in the setting of a hematologic malignancy is common, with the frequency and type of kidney disease varying depending on the specific malignancy. Various glomerular diseases and tumor infiltration of the kidneys have been reported in patients with lymphoproliferative disorders. Descriptions of kidney involvement in myeloproliferative disorders have been much rarer. We report a case of membranous nephropathy accompanied by kidney injury in a patient with primary myelofibrosis with additional features considered related to the patient's myeloproliferative disorder. A 63-year-old patient with primary myelofibrosis underwent kidney biopsy to investigate nephrotic-range proteinuria and reduced kidney function. Histologic analysis revealed mesangial sclerosis and hypercellularity, changes indicative of membranous nephropathy, and infiltration of hematopoietic cells into the renal interstitium, peritubular capillaries, and perirenal tissue consistent with extramedullary hematopoiesis. He was treated with renin-angiotensin blockade and a Janus kinase inhibitor, resulting in improvement in kidney function and proteinuria.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Kidney Diseases - Volume 70, Issue 6, December 2017, Pages 874-877
Journal: American Journal of Kidney Diseases - Volume 70, Issue 6, December 2017, Pages 874-877
نویسندگان
Carole MD, Pierre MD, PhD, Julien MD, Jean-Louis MD, PhD, Anne-Elisabeth MD, PhD,