Silk fibroin nanoparticles support in vitro sustained antibiotic release and osteogenesis on titanium surface

Immobilization of fibroin silk nanoparticles through silanization process on Ti surface increases the surface nano-roughness and hydrophilicity. Modified Ti surface exhibits increased osteoblast adhesion and growth. Antibiotic loaded nanoparticle immobilized surface shows sustained release of antibiotic and no deleterious effect on osteoblast adhesion. Such easy and cost-effective process of orthopedic implant surface modification can open new avenues for economically challenged patients.219