کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
877379 911024 2015 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Nanoparticles in medicine: Current challenges facing inorganic nanoparticle toxicity assessments and standardizations
ترجمه فارسی عنوان
نانو ذرات در پزشکی: چالش های فعلی با ارزیابی و استاندارد سازی نانوذرات غیر ارگانیک
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

Although nanoparticles research is ongoing since more than 30 years, the development of methods and standard protocols required for their safety and efficacy testing for human use is still in development. The review covers questions on toxicity, safety, risk and legal issues over the lifecycle of inorganic nanoparticles for medical applications. The following topics were covered: (i) In vitro tests may give only a very first indication of possible toxicity as in the actual methods interactions at systemic level are mainly neglected; (ii) the science-driven and the regulation-driven approaches do not really fit for decisive strategies whether or not a nanoparticle should be further developed and may receive a kind of “safety label”. (iii) Cost and time of development are the limiting factors for the drug pipeline. Knowing which property of a nanoparticle makes it toxic it may be feasible to re-engineer the particle for higher safety (safety by design).From the Clinical EditorTesting the safety and efficacy of nanoparticles for human use is still in need of standardization. In this concise review, the author described and discussed the current unresolved issues over the application of inorganic nanoparticles for medical applications.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 11, Issue 7, October 2015, Pages 1689–1694
نویسندگان
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