کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
877380 911024 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Size, surface charge, and shape determine therapeutic effects of nanoparticles on brain and retinal diseases
ترجمه فارسی عنوان
اندازه، سطح شستشو و شکل تاثیرات درمانی نانوذرات را بر بیماری های مغز و شبکیه تعیین می کند
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
چکیده انگلیسی

Nanoparticles can be valuable therapeutic options to overcome physical barriers to reach central nervous system. Systemically administered nanoparticles can pass through blood-neural barriers; whereas, locally injected nanoparticles directly reach neuronal and perineuronal cells. In this review, we highlight the importance of size, surface charge, and shape of nanoparticles in determining therapeutic effects on brain and retinal diseases. These features affect overall processes of delivery of nanoparticles: in vivo stability in blood and other body fluids, clearance via mononuclear phagocyte system, attachment with target cells, and penetration into target cells. Furthermore, they are also determinants of nano-bio interfaces: they determine corona formation with proteins in body fluids. Taken together, we emphasize the importance of considerations on characteristics of nanoparticles more suitable for the treatment of brain and retinal diseases in the development of nanoparticle-based therapeutics.From the Clinical EditorThe central nervous system (CNS) remains an area where drug access and delivery are difficult clinically due to the blood brain barrier. With advances in nanotechnology, many researchers have designed and produced nanoparticle-based systems in an attempt to solve this problem. In this concise review, the authors described the current status of drug delivery to the CNS, based on particle size and shape. This article should stimulate more research to be done on future drug design.

Graphical AbstractSize, surface charge, and shape determine various actions of nanoparticles including cellular uptake by reticuloendothelial systems, targeting to target cells, in vivo distribution, and corona formation with proteins in body fluids and matrix structures. In addition, we expect that there are differential effects of nanoparticle characteristics on therapeutic potential according to the administration routes for the treatment of central nervous system diseases. In this context, a wide variety of shapes of nanoparticles can add up diversity and flexibility in the use of nanoparticles for therapeutic application.Figure optionsDownload high-quality image (197 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 11, Issue 7, October 2015, Pages 1603–1611
نویسندگان
, , , ,