کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
877440 | 911026 | 2013 | 20 صفحه PDF | دانلود رایگان |

The extracellular environment which supports cell life is composed of a hierarchy of maintenance, force and regulatory systems which integrate from the nano- through to macroscale. For this reason, strategies to recreate cell supporting environments have been investigating the use of nanocomposite biomaterials. Here, we review the use of carbon nanotubes as part of a bottom-up approach for use in bone tissue engineering. We evaluate the properties of carbon nanotubes in the context of synthetic tissue substrates and contrast them with the nanoscale features of the extracellular environment. Key studies are evaluated with an emphasis on understanding the mechanisms through which carbon nanotubes interact with biological systems. This includes an examination of how the different properties of carbon nanotubes affect tissue growth, how these properties and variation to them might be leveraged in regenerative tissue therapies and how impurities or contaminates affect their toxicity and biological interaction.From the Clinical EditorIn this comprehensive review, the authors describe the status and potential applications of carbon nanotubes in bone tissue engineering.
Graphical AbstractCarbon nanotubes are a unique nanomaterial offering extraordinary mechanical, chemical and electrical properties. Here, we review the use of carbon nanotubes in bone tissue engineering. By leveraging their unique properties tissue engineers can create biocompatible environments with controllable architectural, electrical, chemical and mechanical properties. This includes the presentation of cell binding epitopes, controllable patterns and textures, the modulation of cell shape and fate as well as the enhancement of substrate conductivity and strength. Additionally, their rod-like shape and nanoscale dimensionality makes them a morphological biomimetic of the fibrillar proteins in the extracellular matrix.Figure optionsDownload high-quality image (236 K)Download as PowerPoint slide
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 9, Issue 8, November 2013, Pages 1139–1158