کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8774814 | 1599207 | 2017 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Uso terapéutico de las vesÃculas extracelulares en insuficiencia renal aguda y crónica
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
بیماریهای کلیوی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A new cell-to-cell communication system was discovered in the 1990s, which involves the release of vesicles into the extracellular space. These vesicles shuttle bioactive particles, including proteins, mRNA, miRNA, metabolites, etc. This particular communication has been conserved throughout evolution, which explains why most cell types are capable of producing vesicles. Extracellular vesicles (EVs) are involved in the regulation of different physiological processes, as well as in the development and progression of several diseases. EVs have been widely studied over recent years, especially those produced by embryonic and adult stem cells, blood cells, immune system and nervous system cells, as well as tumour cells. EV analysis from bodily fluids has been used as a diagnostic tool for cancer and recently for different renal diseases. However, this review analyses the importance of EVs generated by stem cells, their function and possible clinical application in renal diseases and kidney transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: NefrologÃa - Volume 37, Issue 2, MarchâApril 2017, Pages 126-137
Journal: NefrologÃa - Volume 37, Issue 2, MarchâApril 2017, Pages 126-137
نویسندگان
Jordi Rovira, Fritz Diekmann, Josep M. Campistol, MarÃa José RamÃrez-Bajo,