Design and development of nanocomposite scaffolds for auricular reconstruction

Auricular reconstruction using sculpted autologous costal cartilage is effective, but complex and time consuming and may incur donor site sequelae and morbidity. Conventional synthetic alternatives are associated with infection and extrusion in up to about 15% of cases. We present a novel POSS-PCU nanocomposite auricular scaffold, which aims to reduce extrusion rates by mimicking the elastic modulus of human ears and by encouraging desirable cellular interactions. The fabrication, physicochemical properties (including nanoscale topography) and cellular interactions of these scaffolds were compared to Medpor®, the current synthetic standard. Our scaffold had a more similar elastic modulus (5.73 ± 0.17 MPa) to ear cartilage (5.02 ± 0.17 MPa) compared with Medpor®, which was much stiffer (140.9 ± 0.04 MPa). POSS-PCU supported fibroblast ingrowth and proliferation; significantly higher collagen production was also produced by cells on the POSS-PCU than those on Medpor®. This porous POSS-PCU nanocomposite scaffold is therefore a promising alternative biomaterial for auricular surgical reconstruction.From the Clinical EditorIn this paper, a novel POSS-PCU nanocomposite auricular scaffold is described to reduce extrusion rates by having a much closer elastic modulus of human ears than the currently available synthetic standard. Enabling desirable cellular interactions may lead to the successful clinical application of these novel scaffolds.

New porous POSS-PCU nanocomposite scaffolds were developed for auricular reconstruction. The physicochemical properties and cellular interactions of these scaffolds were compared with the commercially available synthetic alternative, Medpor®. The solvent evaporation/porogen leaching (POSS-PCUs) scaffold produced a porous scaffold with an elastic modulus similar to native ear cartilage. This POSS-PCUs scaffold also supported fibroblast growth and increased collagen production compared to the phase-separation (coagulation)/porogen leaching (POSS-PCUc) scaffold and Medpor®. By matching the elastic modulus of the scaffold to native tissue and by encouraging desirable cellular interactions, this nanocomposite scaffold can be use as promising alternative biomaterial for replacement of auricular cartilage.Figure optionsDownload high-quality image (123 K)Download as PowerPoint slide