کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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877491 | 911030 | 2012 | 4 صفحه PDF | دانلود رایگان |

Hyaluronic acid (HA), which is a biocompatible, biodegradable, and linear polysaccharide in the body, has been widely used for various biomedical applications. In this work, real-time bioimaging for target-specific delivery of HA derivatives was carried out using quantum dots (QDs). In vitro confocal microscopy of HA-QD conjugates confirmed the intracellular delivery of HA derivatives to B16F1 cells with HA receptors by HA-receptor-mediated endocytosis. Furthermore in vivo real-time confocal microscopy of HA-QD conjugates successfully visualized the target specific delivery and accumulation of HA-QD conjugates from the fluorescence-labeled blood vessels to the liver tissues. The authors could confirm the feasibility of HA derivatives as a target-specific intracellular drug-delivery carrier for the treatment of liver diseases and the in vivo real-time confocal microscopy as a new bioimaging tool for various drug-delivery applications.From the Clinical EditorThis study demonstrates the possibility of labeling hyaluronic acid with quantum dots for visualization and for targeted intracellular drug delivery in liver disease models.
Title: In Vivo Real Time Confocal Microscopy for Target Specific Delivery of Hyaluronic Acid - Quantum Dot ConjugatesIn vivo real-time confocal microscopy of HA-QDot conjugates successfully visualized the target specific delivery and accumulation of HA-QDot conjugates from the fluorescence-labeled blood vessels to the liver tissues, which confirmed the feasibility of HA derivatives as a target specific intracellular drug delivery carrier for the treatment of liver diseases.Figure optionsDownload high-quality image (156 K)Download as PowerPoint slide
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 8, Issue 7, October 2012, Pages 1070–1073