کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
877508 911030 2012 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
pH-Dependent nanostructure based on isoquinoline-cyclodextrin conjugate for thrombosis therapy
چکیده انگلیسی

The modification of 3S-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA) with β-cyclodextrin (β-CD) provides an oral antithrombotic agent, 6-(3′S-isoquinoline-3′-carboxylaminoethylamino)-6-deoxy-β-CD (THIQA-β-CD). In aqueous solution THIQA-β-CD undergoes intermolecular inclusion complexation and forms pH-dependent nanostructures. The morphological feature of THIQA-β-CD is a nanocloud consisting of numerous particles that are 5 nm–6 nm in diameter at pH 3.0. The nanocloud switches to a nanorod ranging from 100 nm to 385 nm in length at pH 7.2, then to nanowires of 50 nm to 530 nm in length at pH 10.1. THIQA-β-CD, which has unusual nanostructures, offers enhanced stability in blood. Inhibition of thrombin-induced platelet aggregation in vitro and demonstrated antithrombotic efficacy in vivo. This investigation demonstrated that the modification of THIQA with β-CD is a promising approach for clinical therapy of thrombus disease. The pH-dependent nanostructures of conjugate provide the desired in vivo antithrombotic activity and in vitro stability in blood.From the Clinical EditorThis study a demonstrates that the modification of 3S-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA) with beta-cyclodextrin, which leads to pH dependent nanostructure formation, is a promising approach for clinical therapy of thrombotic disease.

Graphical AbstractThe modification of 3S-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid (THIQA) with β-cyclodextrin (β-CD) provides an oral anti-thrombotic agent, THIQA-β-CD. In aqueous solution THIQA-β-CD undergoes self-assembly and forms pH-dependent nanostructures via intermolecular inclusion complexation. THIQA-β-CD with unusual nanostructures offers enhanced stability in blood, inhibition of thrombin induced platelet aggregation in vitro and high in vivo anti-thrombotic efficacy.Figure optionsDownload high-quality image (87 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 8, Issue 7, October 2012, Pages 1216–1222
نویسندگان
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