Marine actinobacterial mediated gold nanoparticles synthesis and their antimalarial activity

Streptomyces sp LK-3 (JF710608) mediated Gold nanoparticles (Au-N-LK3) were found within the size range of 5-50 nm. Au-N-LK3 treatment in Plasmodium berghei ANKA (PbA) infected mice delayed the parasitemia rise (~ 6%) compared to PbA infection on 8 days post infection. Survivability of mice increases to ~ 85% in Au-N-LK3 treated mice in contrast to in PbA (~ 50%) infected mice in 8 dpi with respect to control. During Au-N-LK3 treatment in PbA infection, histomorphological analysis revealed as such no change in spleen and liver tissue during 8 dpi. Our results confirmed up-regulation of TGF-β and down-regulation of TNF-α in tissue and serum level in PbA infected Au-N-LK3 treated mice compared to PbA infection. No significant changes were found in the hatchability of Artemia embryos upto 8 mg. The results obtained suggest that the Au-N-LK3 possess anti-malarial activity and could be considered as a potential source for anti-malarial drug development.From the Clinical EditorThese investigators present a method of marine actinobacteria mediated synthesis of gold nanoparticles, resulting in nanoparticles that possess anti-malarial activity and could be considered in future anti-malarial drug development.

Graphical AbstractGold nanoparticles have been widely known for many centuries. Au-N-LK3, new antimalarial medicines are poised to have a dramatic impact on global health by helping to reduce the malarial burden, eventually pushing the parasite toward eradicationFigure optionsDownload high-quality image (215 K)Download as PowerPoint slide