کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
877560 911033 2013 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Photoactivation of gold nanoparticles for glioma treatment
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Photoactivation of gold nanoparticles for glioma treatment
چکیده انگلیسی

Radiosensitization efficacy of gold nanoparticles (AuNPs) with low energy radiations (88 keV) was evaluated in vitro and in vivo on rats bearing glioma. In vitro, a significant dose-enhancement factor was measured by clonogenic assays after irradiation with synchrotron radiation of F98 glioma cells in presence of AuNPs (1.9 and 15 nm in diameter). In vivo, 1.9 nm nanoparticles were found to be toxic following intracerebral delivery in rats bearing glioma, whether no toxicity was observed using 15 nm nanoparticles at the same concentration (50 mg/mL). The therapeutic efficacy of gold photoactivation was determined by irradiating the animals after intracerebral infusion of AuNPs. Survival of rats that had received the combination of treatments (AuNPs: 50 mg/mL, 15 Gy) was significantly increased in comparison with the survival of rats that had received irradiation alone. In conclusion, this experimental approach is promising and further studies are foreseen for improving its therapeutic efficacy.From the Clinical EditorThese investigators report that gold nanoparticles of the correct size can be used to enhance the effects of irradiation in the context of a glioma model. Since many of the glioma varieties are currently incurable, this or similar approaches may find their way to clinical trials in the near future.

Graphical AbstractThe combination of gold nanoparticles with low energy synchrotron irradiation enhances the efficacy of glioma treatment in comparison with radiation alone both in vitro and in vivo. Distribution of gold nanoparticles in the brain was determined by 3D synchrotron computed tomography.Figure optionsDownload high-quality image (170 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 9, Issue 7, October 2013, Pages 1089–1097
نویسندگان
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