کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
877716 911042 2013 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development, characterization and efficacy of niosomal diallyl disulfide in treatment of disseminated murine candidiasis
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Development, characterization and efficacy of niosomal diallyl disulfide in treatment of disseminated murine candidiasis
چکیده انگلیسی

In the current study, a novel niosome based formulation of diallyl disulfide (DADS) was evaluated for its potential to treat disseminated candidiasis in mouse model. Among various non-ionic surfactants tested, niosome formulation prepared using Span 80 was found to be most efficient in the entrapment of DADS. The DADS loaded niosomes had size dimensions in the range of 140 ± 30 nm with zeta potential of − 30.67 ± 4.5. Liver/kidney function tests as well as histopathologic studies suggested that noisome-based DADS formulations are safe at the dose investigated. When administered to Candida albicans infected animals, the DADS bearing niosomal formulation cleared the fungal burden and increased their survival much efficiently than its free form.From the Clinical EditorIn this study, a novel niosomal formulation of the antifungal DADS was utilized in a murine candidiasis model, resulting in more efficient fungal clearance compared to the free formulation.

Graphical AbstractOn incorporation of DADS in non-ionic surfactant based niosomes, it reduces fungal burden and increases survival in infected animals significantly compared with free form of DADS.Figure optionsDownload high-quality image (153 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 9, Issue 2, February 2013, Pages 247–256
نویسندگان
, , , , , , , ,