کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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877794 | 911047 | 2012 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice Nitric oxide-releasing nanoparticles accelerate wound healing in NOD-SCID mice](/preview/png/877794.png)
Wound healing is a complex process, coordinated by various biological factors. In immunocompromised states wound healing can be interrupted as a result of decreased numbers of immune cells, impairing the production of effector molecules such as nitric oxide (NO). Therefore, topical NO-releasing platforms, such as diethylenetriamine (DETA NONOate), have been investigated to enhance wound healing. Recently, we demonstrated a nanoparticle platform that releases NO (NO-NPs) in a sustained manner, accelerating wound healing in both uninfected and infected murine wound models. Here, NO-NPs were investigated and compared to DETA NONOate in an immunocompromised wound model using non-obese, diabetic, severe combined immunodeficiency mice. NO-NP treatment accelerated wound closure as compared to controls and DETA NONOate treatment. In addition, histological assessment revealed that wounds treated with NO-NPs had less inflammation, more collagen deposition, and more blood vessel formation as compared to other groups, consistent with our previous data in immunocompetent animals. These data suggest that NO-NPs may serve as a novel wound-healing therapy in the setting of immunocompromised states associated with impaired wound healing.From the Clinical EditorWound healing in an immunocompromised host is often incomplete and is a source of major concern in such conditions. This work demonstrates in a murine model that in these settings NO releasing nanoparticles significantly enhance wound healing.
Graphical AbstractEvery other day dosing of a novel nitric oxide (NO) releasing nanoparticle platform applied to a splinted 5 mm punch biopsy full thickness wound in NOD-SCID mice resulted in accelerated wound closure as compared to controls, and as shown here, to comparable doses of a well known NO donor, DETA NONOate.Figure optionsDownload high-quality image (160 K)Download as PowerPoint slide
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 8, Issue 8, November 2012, Pages 1364–1371