Formulation and optimization of nanotransfersomes using experimental design technique for accentuated transdermal delivery of valsartan

The purpose of this work was to develop and statistically optimize nanotransfersomes for enhanced transdermal of valsartan vis-à-vis traditional liposomes. Nanotransfersomes bearing valsartan were prepared by conventional rotary evaporation method and characterized for various parameters including entrapment efficiency, vesicles shape, size, size distribution, and skin permeation. In vivo antihypertensive activity conducted on Wistar rats was also taken as a measure of performance of nanotransfersomes and liposomes. Nanotransfersomes proved significantly superior in terms of amount of drug permeated in the skin, with an enhancement ratio of 33.97 ± 1.25 when compared to rigid liposomes. This was further confirmed through a confocal laser scanning microscopy study. Nanotransfersomes showed better antihypertensive activity in comparison to liposomes by virtue of better permeation through Wistar rat skin. Finally, it could be concluded that the nanotransfersomes accentuates the transdermal flux of valsartan and could be used as a carrier for effective transdermal delivery of valsartan.From the Clinical EditorIn this paper, the authors discuss the development and optimization of nanotransfersomes for enhanced transdermal of valsartan and demonstrate accentuated transdermal compared to standard preparations.

Graphical AbstractValsartan-bearing nanotransfersomes were successfully prepared by conventional rotary evaporation sonication method. Nanotransfersomes were characterized for various parameters including entrapment efficiency, vesicles shape, size, size distribution, and skin permeation. Flexible nanotransfersomes provided better flux and higher entrapment efficiency, and proved significantly superior in terms of amount of drug permeated in the skin, when compared to rigid liposomes. Because Transfersomes are composed of surfactant and have better rheology and hydration properties, they have superior skin penetration ability over traditional liposomes, which are confined to the skin surface.Figure optionsDownload high-quality image (165 K)Download as PowerPoint slide