کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
878031 911058 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Highly electroconductive multiwalled carbon nanotubes as potentially useful tools for modulating calcium balancing in biological environments
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Highly electroconductive multiwalled carbon nanotubes as potentially useful tools for modulating calcium balancing in biological environments
چکیده انگلیسی

Aiming to explore the mechanisms modulating cell-carbon nanotube interactions, we investigated whether Ca2+ ion balancing between intra- and extracellular environments could be affected by multiwalled carbon nanotubes (MWCNTs). We analyzed the effects induced by two different kinds of MWCNTs (as prepared and annealed at 2400°C) on the intracellular Ca2+ ion levels in rat electrically sensitive cells and on the intercellular junction integrity of rat adenocarcinoma colon cells and platelet aggregation ability, which depend on the Ca2+ concentration in the medium. MWCNTs, purified by annealing and more electroconductive as compared to nonannealed MWCNTs, affected Ca2+ ion balancing between extra- and intracellular environments and induced changes on Ca2+ ion-dependent cellular junctions and platelet aggregation, behaving as the calcium chelator ethylene glycol tetraacetic acid. This could be due to the sorption of cationic Ca2+ ions on CNTs surface because of the excess of negatively charged electrons on the aromatic units formed on MWCNTs after annealing.From the Clinical EditorThe authors investigated whether Ca2+ ion balance between intra- and extracellular space can be modulated by multiwalled carbon nanotubes (MWCNTs). Annealed nanotubes induced changes on Ca2+ dependent cellular junctions and platelet aggregation, behaving similary to ethylene glycol tetraacetic acid, an established calcium chelator.

Graphical AbstractPurified by annealing and electro-conductive MWCNTs affect Ca++ ion balancing between extra and intracellular environments, inducing: i) an early increase in cytosolic Ca++ ion levels in electrically sensitive neuronal-derived cells, possibly due to Ca++ mobilization from the intracellular storage compartments; ii) disruption of Ca++ ion-dependent cell-cell junction integrity; iii) decreased Ca++ ion-dependent platelet aggregation ability. These effects are likely due to the sorption of the cationic Ca++ ions on carbon nanotube surface because of the excess of negatively charged electrons on the aromatic units formed on MWCNTs after annealing.Figure optionsDownload high-quality image (159 K)Download as PowerPoint slide

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 8, Issue 3, April 2012, Pages 299–307
نویسندگان
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