کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
878149 911064 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies
موضوعات مرتبط
مهندسی و علوم پایه سایر رشته های مهندسی مهندسی پزشکی
پیش نمایش صفحه اول مقاله
Mechanism of alpha-synuclein oligomerization and membrane interaction: theoretical approach to unstructured proteins studies
چکیده انگلیسی

Misfolding and oligomerization of unstructured proteins is involved in the pathogenesis of Parkinson's disease (PD), Alzheimer's disease, Huntington's disease, and other neurodegenerative disorders. Elucidation of possible conformations of these proteins and their interactions with the membrane is necessary to understand the molecular mechanisms of neurodegeneration. We developed a strategy that makes it possible to elucidate the molecular mechanisms of α-synuclein aggregation—a key molecular event in the pathogenesis of PD. This strategy can be also useful for the study of other unstructured proteins involved in neurodegeneration. The results of these theoretical studies have been confirmed with biochemical and electrophysiological studies. Our studies provide insights into the molecular mechanism for PD initiation and progression, and provide a useful paradigm for identifying possible therapeutic interventions through computational modeling.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 4, Issue 4, December 2008, Pages 350–357
نویسندگان
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