کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8783269 1600751 2017 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Importance of the assessment of intracellular Ca2+ level as diagnostic tool of dysfunctional sperm
ترجمه فارسی عنوان
اهمیت ارزیابی سطح کلسیم داخل سلولی به عنوان ابزار تشخیص اسپرم ناکارآمد است
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی
Sperm functions are an important factor for fertility/pregnancy to be achieved. Sperm dysfunction is the most common cause of male infertility. The best option to help couples with such male factor to achieve a pregnancy, is using Assisted Reproductive Technology (ART), without defining the underlying cause of sperm dysfunction or male-factor infertility in general at the cellular and molecular levels. Thus, the limited success of ART in a proportion of male infertility cases is unsurprising. Ca2+ signalling plays a fundamental role in the regulation of sperm function. Interestingly, it appears that the potential exists to diagnose abnormalities in the Ca2+ channels that underlie sperm dysfunction. This raises the potential for future drug discovery to try to correct this defect by augmenting Ca2+ signalling such as Ca2+ store mobilisation or activating CatSper, as possible rational treatments for sperm dysfunction that may temporarily increase the capacity to interact with the egg. Such a pharmacological agent may provide a useful way of increasing the effectiveness of IUI or IVF over conventional IUI and IVF procedures.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Middle East Fertility Society Journal - Volume 22, Issue 3, September 2017, Pages 170-173
نویسندگان
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