کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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878389 | 911080 | 2006 | 13 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Adaptations of nanoscale viruses and other protein cages for medical applications Adaptations of nanoscale viruses and other protein cages for medical applications](/preview/png/878389.png)
Nanosized materials (5-100 nm) with multiple functionalities (cell targeting, drug delivery, and bio-imaging) have emerged over the recent years as promising therapeutic agents. Liposomal carriers, amphiphilic co-polymers, silica-based particles, colloidal systems, and dendrimer clusters are among the many available nanoscale scaffolds that have been explored for medical applications such as gene delivery, bio-imaging, and drug delivery. On the other hand, viruses, ferritin, and other protein cages for ages have self-organized in the nanometer range with biologically relevant functionalities. These bio-inspired systems form monodispersed units that are highly amendable through genetic and chemical modifications. In this review the expansion of these protein-based nanosystems, termed bionanoparticles (BNPs), beyond their native functionalities, and their application as building materials for nanomedicine will be discussed. The recent developments of biology-inspired systems with potential medical applications will be outlined, with particular emphasis on adaptations of protein-based nanostructures for gene delivery, bio-imaging, drug encapsulation, and vaccine development. Notable systems already streamlined for medical applications are recombinant virus-like particles derived from human papillomaviruses as multivalent vaccine carriers to immunize patients against genital infections, and vaccinia viruses to treat patients with established cancers.
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 2, Issue 3, September 2006, Pages 137–149