کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8784335 1600937 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Placenta-directed gene therapy for fetal growth restriction
ترجمه فارسی عنوان
ژن درمانی مستقر در محل تزریق برای محدود کردن رشد جنین
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی
Fetal growth restriction (FGR) is a serious pregnancy complication affecting ∼8% of all pregnancies. There is no treatment to increase fetal growth in the uterus. Gene therapy presents a promising treatment strategy for FGR, with the use of adenoviral vectors encoding for proteins such as vascular endothelial growth factor (VEGF) and insulin-like growth factor demonstrating improvements in fetal growth, placental function, and neonatal outcome in preclinical studies. Safety assessments suggest no adverse risk to the mother or fetus for VEGF maternal gene therapy; a clinical trial is in development. This review assesses research into placenta-directed gene therapy for FGR, investigating the use of transgenes and vectors, their route of administration in obstetrics, and the steps that will be needed to take this treatment modality into the clinic.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Fetal and Neonatal Medicine - Volume 22, Issue 6, December 2017, Pages 415-422
نویسندگان
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