Randomized open-labbel non-inferiority trial of acetaminophen or loxoprofen for patients with acute low back pain

The results suggest that acetaminophen has comparable analgesic effects on acute LBP, based on at least a noninferiority margin, compared with loxoprofen at 4 weeks. Acetaminophen seems to be a reasonable first-line option for patients with acute LBP in Japan.