کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8807440 | 1606631 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Clinicopathological analysis of immunohistochemical expression of retinoic acid-related orphan receptor-γt in peripheral T-cell lymphoma, not otherwise specified
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موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
آسیبشناسی و فناوری پزشکی
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چکیده انگلیسی
Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS) is cytologically and phenotypically heterogeneous. Retinoic acid-related orphan receptor-γt (RORγt) is a transcription factor that regulates the differentiation of naïve CD4+ helper T cells to Th17 cells. In the present study, we immunohistochemically confirmed the expression of RORγt in PTCL-NOS. Pathological and clinical investigations were performed for 170 cases of PTCL-NOS. RORγt-positive cases accounted for 17.6% (30/170) of the total cases, and they showed a significantly higher frequency of CD8 positivity (Pâ¯=â¯.033), lower counts of white blood cells (Pâ¯=â¯.030) and neutrophils (Pâ¯=â¯.039) in the peripheral blood, higher levels of hypergammaglobulinemia (Pâ¯=â¯.031), a higher frequency of a complete response (Pâ¯=â¯.009), and a tendency for a lower International Prognostic Index (Pâ¯=â¯.061) and better overall survival (Pâ¯=â¯.0806). These results suggest that RORγt-positive PTCL-NOS could be a subpopulation of PTCL-NOS. Further research associated with this genomic abnormality at the transcriptional level is needed to confirm the results of this study.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Human Pathology - Volume 79, September 2018, Pages 86-92
Journal: Human Pathology - Volume 79, September 2018, Pages 86-92
نویسندگان
Eriko MD, Hiroaki MD, PhD, Keisuke MD, PhD, Kazutaka MT, Kotaro MD, Kyohei MD, Reiji MD, Koji MD, PhD, Masao MD, PhD, Koichi MD, PhD,