The role of preoperative intra muscular testosterone in improving functional and cosmetic outcomes following hypospadias repair: A prospective randomized study

Two systematic reviews on the role of preoperative testosterone failed to reach any conclusion. One described a glans width <14 mm as a risk factor for urethral complications after hypospadias repair but another did not support this. Our findings reveal that preoperative testosterone significantly increases the glans width thereby reducing the complications and requirement for reoperation. It also improves the cosmetic outcomes and parental satisfaction.Table. Comparison of the functional and cosmetic outcomes among the groups.No TST group 1 (n = 92)TST group 2 (n = 94)Group 1 vs. 2a (p)Group 1 vs. 2b (p)Group 2a vs. 2b(p)TST-non responders group 2a (n = 16) 17%TST responder group 2b (n = 78) 83%Urethrocutaneous fistula7 (7.6%)2 (12.5%)4 (5.1%)0.610.750.26Glans dehiscence13 (14.1%)4 (25%)3 (3.9%)0.260.020.03Meatal stenosis6 (6.5%)2 (12.5%)7 (8.9%)0.320.570.64Total complications26 (28.3%)8 (50%)14 (18%)0.080.150.01Reoperations22 (23.9%)5 (31.3%)9 (11.5%)0.530.040.06Mean PPPS (SD)8.03 ± 1.558.06 ± 0.688.88 ± 2.200.950.0030.1Parents satisfied with cosmesis72 (78%)11 (69%)71 (91%)0.520.030.03