کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8813083 | 1607687 | 2018 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Early diagnosis of severe infection
ترجمه فارسی عنوان
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پریناتولوژی (پزشکی مادر و جنین)، طب اطفال و بهداشت کودک
چکیده انگلیسی
Sepsis is recognised as a global health concern and has a high morbidity and mortality. Evidence shows that mortality rates can be reduced by up to 50% through early recognition and treatment. However, indiscriminate antibiotic use can lead to resistant microbial strains, and increased cost. Sepsis is newly redefined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Screening tools exist and the UK National Institute for Health and Care Excellence (NICE) provide a recommended screening tool which identifies most children at risk from sepsis. Current biomarkers do not reliably differentiate between sepsis and inflammation, and show a delayed response (12-24 hours) to bacterial infection. Evolving research shows procalcitonin is a biomarker released in response to inflammatory stimuli during bacterial infections, with very high levels produced in sepsis and enables real-time monitoring. This review discusses the new definitions of sepsis, importance of making an early diagnosis with appropriate investigations and future diagnostic advancements.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Paediatrics and Child Health - Volume 28, Issue 6, June 2018, Pages 249-253
Journal: Paediatrics and Child Health - Volume 28, Issue 6, June 2018, Pages 249-253
نویسندگان
Rachel J. McGalliard, Enitan D. Carrol,