Experiencia con ibuprofeno para el tratamiento de la persistencia de conducto arterioso en un hospital de tercer nivel en la Ciudad de México

There were no statistical differences in the rate of success for the closure of patent ductus arteriosus with the first or second cycle of ibuprofen (47.7% vs 42.8%) (p = 1). With ibuprofen dosages actually used, the success rate for the closure of PDA is less with the second cycle than with the first one, but is not significant. There were no differences as regards IV fluids, neonatal sepsis, mechanical ventilation, or diuretics. Starting treatment after the 5th day is associated with an increase in the failure rate.