Deficits of perceived spatial separation-induced prepulse inhibition in patients with bipolar disorder compared to healthy controls

Patients with BD show a sensorimotor gating deficit as measured by perceived spatial separation-induced PPI of the startle response, which was more sensitive compared to the classic PPI paradigm. Euthymic bipolar patients and depressive bipolar patients show similar PPI level. PPI deficit in patients with BD is related to cognition, but not with demographic and clinical characteristics.