کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
8815026 1608085 2018 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MicroRNAs in depression and suicide: Recent insights and future perspectives
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی روانپزشکی و بهداشت روانی
پیش نمایش صفحه اول مقاله
MicroRNAs in depression and suicide: Recent insights and future perspectives
چکیده انگلیسی
Suicide is a major public health concern. A significant proportion of depressed individuals show suicidal ideation. The currently available medications are not optimal and a large number of depressed/suicidal patients do not respond to these medications. Thus, there is an urgent need to fully understand the neurobiological mechanisms associated with depression and suicidal behavior and to find novel targets for therapeutic interventions. In this regard, microRNAs (miRNAs), member of small non-coding RNA family, have emerged as an invaluable tool not only to understand disease pathogenesis but also to precisely pinpoint the targets that can be developed as drugs. In this review, these aspects have been discussed in a comprehensive and critical manner.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Affective Disorders - Volume 240, November 2018, Pages 146-154
نویسندگان
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