GSK-3b 50 T/C polymorphism in bipolar disorder and its relationship with clinical phenotypes and treatment response

- GSK-3b is hypothesized to play an important role in the etio-pathogenesis of Bipolar Disorder.
- GSK-3b 50 T/C polymorphism alters the transcriptional activity of the gene.
- GSK 3b 50T/C polymorphism was not found to have any association with Bipolar Disorder clinical variables including lithium response.