Dorsomedial frontal cortical metabolic differences of comorbid generalized anxiety disorder in refractory major depression: A [18F] FDG PET brain imaging study

The impaired dmFC metabolic activity observed in comorbid GAD within refractory MDD may be indicative of specific emotional dysfunctional top-down processing in this subgroup, conform the anxiety state. Additional psychotherapeutic interventions may be warranted.