Mechanism of Premature Apoptosis in CD1d-Restricted Natural Killier T Cells From Human Peripheral Blood During the Induction of Proliferation In Vitro

The proliferation of the NKT cells continued for approximately 3 weeks, and then apoptosis Semiconstitutively started to occur. The activity of Caspase-3 was maintained at a high level from the second week. The responses of individual human NKT cells to α-GalCer stimulation differed significantly.